Molecular Characterization of Rifampicin-Resistant Staphylococcus aureus Isolates from Retail Foods in China

Molecular Characterization of Rifampicin-Resistant Staphylococcus aureus Isolates from Retail Foods in China

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This study investigated the molecular characteristics of rifampin-resistant (RIF-R) Staphylococcus aureus isolates recovered from 4300 retail food samples covering most provincial capitals in China, from 2011 to 2016.Of the 1463 S.aureus enrolled, 149 isolates (142 MSSA and 7 MRSA) were identified as rifampicin-resistant, including 20 high-level (MICs ≥ 8 μg/mL) and 129 low-level (MICs between 2 and 4 μg/mL) rifampicin-resistant strains.Most of the RIF-R S.aureus isolates were resistant to more than three antibiotics.

The mutations in the rifampicin resistance-determining region of the rpoB gene were studied in all RIF-R strains.All natio glide on eyeshadow stick of the strains presented the mutational change 481 His/Asn and five isolates presented an additional mutation, including 477 Asp/Tyr, 527 Ile/Met, and 466 Leu/Ser, respectively.Thirteen STs and twenty-one spa types were represented, in which five MRSA showed non-type SCCmec and the remaining MRSA belonged to SCCmec type IV—where, ST1-t127 was the predominant type from all of the isolates, while ST398-t034 was the predominant type for the MRSA isolates.In this study, we found that the food-related RIF-R S.aureus may have a unique genetic background selection.

However, the scenario regarding the presence of RIF-R S.aureus, especially MRSA, in retail food in kicker pro comp 10 China is not favorable and warrants public attention.